FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression
Identifieur interne : 000C68 ( Main/Corpus ); précédent : 000C67; suivant : 000C69FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression
Auteurs : Christian Wider ; Justus C. Dachsel ; Alexandra I. Soto ; Michael G. Heckman ; Nancy N. Diehl ; Mei Yue ; Sarah Lincoln ; Jan O. Aasly ; Kristoffer Haugarvoll ; John Q. Trojanowski ; Spiridon Papapetropoulos ; Deborah Mash ; Alex Rajput ; Ali H. Rajput ; J. Mark Gibson ; Timothy Lynch ; Dennis W. Dickson ; Ryan J. Uitti ; Zbigniew K. Wszolek ; Matthew J. Farrer ; Owen A. RossSource :
- Movement Disorders [ 0885-3185 ] ; 2009-02-15.
English descriptors
- KwdEn :
Abstract
Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22442
Links to Exploration step
ISTEX:4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title><author><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Soto, Alexandra I" sort="Soto, Alexandra I" uniqKey="Soto A" first="Alexandra I." last="Soto">Alexandra I. Soto</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Yue, Mei" sort="Yue, Mei" uniqKey="Yue M" first="Mei" last="Yue">Mei Yue</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Lincoln, Sarah" sort="Lincoln, Sarah" uniqKey="Lincoln S" first="Sarah" last="Lincoln">Sarah Lincoln</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><mods:affiliation>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Papapetropoulos, Spiridon" sort="Papapetropoulos, Spiridon" uniqKey="Papapetropoulos S" first="Spiridon" last="Papapetropoulos">Spiridon Papapetropoulos</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Mash, Deborah" sort="Mash, Deborah" uniqKey="Mash D" first="Deborah" last="Mash">Deborah Mash</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><mods:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name><affiliation><mods:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><mods:affiliation>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2</idno><date when="2009" year="2009">2009</date><idno type="doi">10.1002/mds.22442</idno><idno type="url">https://api.istex.fr/document/4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000C68</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title><author><name sortKey="Wider, Christian" sort="Wider, Christian" uniqKey="Wider C" first="Christian" last="Wider">Christian Wider</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Dachsel, Justus C" sort="Dachsel, Justus C" uniqKey="Dachsel J" first="Justus C." last="Dachsel">Justus C. Dachsel</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Soto, Alexandra I" sort="Soto, Alexandra I" uniqKey="Soto A" first="Alexandra I." last="Soto">Alexandra I. Soto</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Heckman, Michael G" sort="Heckman, Michael G" uniqKey="Heckman M" first="Michael G." last="Heckman">Michael G. Heckman</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Diehl, Nancy N" sort="Diehl, Nancy N" uniqKey="Diehl N" first="Nancy N." last="Diehl">Nancy N. Diehl</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Yue, Mei" sort="Yue, Mei" uniqKey="Yue M" first="Mei" last="Yue">Mei Yue</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Lincoln, Sarah" sort="Lincoln, Sarah" uniqKey="Lincoln S" first="Sarah" last="Lincoln">Sarah Lincoln</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Aasly, Jan O" sort="Aasly, Jan O" uniqKey="Aasly J" first="Jan O." last="Aasly">Jan O. Aasly</name><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Haugarvoll, Kristoffer" sort="Haugarvoll, Kristoffer" uniqKey="Haugarvoll K" first="Kristoffer" last="Haugarvoll">Kristoffer Haugarvoll</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</mods:affiliation></affiliation></author><author><name sortKey="Trojanowski, John Q" sort="Trojanowski, John Q" uniqKey="Trojanowski J" first="John Q." last="Trojanowski">John Q. Trojanowski</name><affiliation><mods:affiliation>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</mods:affiliation></affiliation></author><author><name sortKey="Papapetropoulos, Spiridon" sort="Papapetropoulos, Spiridon" uniqKey="Papapetropoulos S" first="Spiridon" last="Papapetropoulos">Spiridon Papapetropoulos</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Mash, Deborah" sort="Mash, Deborah" uniqKey="Mash D" first="Deborah" last="Mash">Deborah Mash</name><affiliation><mods:affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Alex" sort="Rajput, Alex" uniqKey="Rajput A" first="Alex" last="Rajput">Alex Rajput</name><affiliation><mods:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</mods:affiliation></affiliation></author><author><name sortKey="Rajput, Ali H" sort="Rajput, Ali H" uniqKey="Rajput A" first="Ali H." last="Rajput">Ali H. Rajput</name><affiliation><mods:affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</mods:affiliation></affiliation></author><author><name sortKey="Gibson, J Mark" sort="Gibson, J Mark" uniqKey="Gibson J" first="J. Mark" last="Gibson">J. Mark Gibson</name><affiliation><mods:affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Lynch, Timothy" sort="Lynch, Timothy" uniqKey="Lynch T" first="Timothy" last="Lynch">Timothy Lynch</name><affiliation><mods:affiliation>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</mods:affiliation></affiliation></author><author><name sortKey="Dickson, Dennis W" sort="Dickson, Dennis W" uniqKey="Dickson D" first="Dennis W." last="Dickson">Dennis W. Dickson</name><affiliation><mods:affiliation>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Uitti, Ryan J" sort="Uitti, Ryan J" uniqKey="Uitti R" first="Ryan J." last="Uitti">Ryan J. Uitti</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Wszolek, Zbigniew K" sort="Wszolek, Zbigniew K" uniqKey="Wszolek Z" first="Zbigniew K." last="Wszolek">Zbigniew K. Wszolek</name><affiliation><mods:affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Farrer, Matthew J" sort="Farrer, Matthew J" uniqKey="Farrer M" first="Matthew J." last="Farrer">Matthew J. Farrer</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author><author><name sortKey="Ross, Owen A" sort="Ross, Owen A" uniqKey="Ross O" first="Owen A." last="Ross">Owen A. Ross</name><affiliation><mods:affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15">2009-02-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="455">455</biblScope><biblScope unit="page" to="459">459</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2</idno><idno type="DOI">10.1002/mds.22442</idno><idno type="ArticleID">MDS22442</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>FGF20</term><term>Parkinson's disease</term><term>association study</term><term>genetics</term><term>α‐synuclein</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Christian Wider MD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string><json:string>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Justus C. Dachsel PhD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Alexandra I. Soto BS</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Michael G. Heckman MS</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Nancy N. Diehl BS</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Mei Yue MD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Sarah Lincoln BSc</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Jan O. Aasly MD, PhD</name><affiliations><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string><json:string>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>Kristoffer Haugarvoll MD, PhD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string><json:string>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</json:string></affiliations></json:item><json:item><name>John Q. Trojanowski MD, PhD</name><affiliations><json:string>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</json:string></affiliations></json:item><json:item><name>Spiridon Papapetropoulos MD, PhD</name><affiliations><json:string>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</json:string></affiliations></json:item><json:item><name>Deborah Mash PhD</name><affiliations><json:string>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</json:string></affiliations></json:item><json:item><name>Alex Rajput FRCPC</name><affiliations><json:string>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</json:string></affiliations></json:item><json:item><name>Ali H. Rajput FRCPC</name><affiliations><json:string>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</json:string></affiliations></json:item><json:item><name>J. Mark Gibson MD</name><affiliations><json:string>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</json:string></affiliations></json:item><json:item><name>Timothy Lynch MD</name><affiliations><json:string>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</json:string></affiliations></json:item><json:item><name>Dennis W. Dickson MD</name><affiliations><json:string>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Ryan J. Uitti MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Zbigniew K. Wszolek MD</name><affiliations><json:string>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Matthew J. Farrer PhD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item><json:item><name>Owen A. Ross PhD</name><affiliations><json:string>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Parkinson's disease</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>FGF20</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α‐synuclein</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>association study</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genetics</value></json:item></subject><articleId><json:string>MDS22442</json:string></articleId><language><json:string>eng</json:string></language><abstract>Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society</abstract><qualityIndicators><score>5.512</score><pdfVersion>1.6</pdfVersion><pdfPageSize>612 x 810 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>679</abstractCharCount><pdfWordCount>2800</pdfWordCount><pdfCharCount>18748</pdfCharCount><pdfPageCount>5</pdfPageCount><abstractWordCount>101</abstractWordCount></qualityIndicators><title>FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title><genre><json:string>article</json:string></genre><host><volume>24</volume><publisherId><json:string>MDS</json:string></publisherId><pages><total>5</total><last>459</last><first>455</first></pages><issn><json:string>0885-3185</json:string></issn><issue>3</issue><subject><json:item><value>Brief Report</value></json:item></subject><genre><json:string>Journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1531-8257</json:string></eissn><title>Movement Disorders</title><doi><json:string>10.1002/(ISSN)1531-8257</json:string></doi></host><publicationDate>2009</publicationDate><copyrightDate>2009</copyrightDate><doi><json:string>10.1002/mds.22442</json:string></doi><id>4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2</id><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><availability><p>WILEY</p></availability><date>2009</date></publicationStmt><notesStmt><note type="content">*Potential conflict of interest: None reported.</note><note>Swiss National Science Foundation</note><note>Swiss Parkinson Foundation</note><note>Robert H. and Clarice Smith and the M.L. Simpson Foundation Trust</note><note>Michael J. Fox Foundation</note><note>Morris K. Udall Center of Excellence for Parkinson's Disease Research - No. P50‐NS40256;</note><note>Mayo Clinic ADRC - No. P50‐AG16574;</note><note>Pacific Alzheimer Research Foundation (PARF) - No. C06‐01;</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title><author><persName><forename type="first">Christian</forename><surname>Wider</surname></persName><roleName type="degree">MD</roleName><note type="correspondence"><p>Correspondence: Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road South, Jacksonville, Florida 32224</p></note><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Justus C.</forename><surname>Dachsel</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Alexandra I.</forename><surname>Soto</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Michael G.</forename><surname>Heckman</surname></persName><roleName type="degree">MS</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Nancy N.</forename><surname>Diehl</surname></persName><roleName type="degree">BS</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Mei</forename><surname>Yue</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Sarah</forename><surname>Lincoln</surname></persName><roleName type="degree">BSc</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Jan O.</forename><surname>Aasly</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</affiliation></author><author><persName><forename type="first">Kristoffer</forename><surname>Haugarvoll</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation></author><author><persName><forename type="first">John Q.</forename><surname>Trojanowski</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</affiliation></author><author><persName><forename type="first">Spiridon</forename><surname>Papapetropoulos</surname></persName><roleName type="degree">MD, PhD</roleName><affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</affiliation></author><author><persName><forename type="first">Deborah</forename><surname>Mash</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</affiliation></author><author><persName><forename type="first">Alex</forename><surname>Rajput</surname></persName><roleName type="degree">FRCPC</roleName><affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</affiliation></author><author><persName><forename type="first">Ali H.</forename><surname>Rajput</surname></persName><roleName type="degree">FRCPC</roleName><affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</affiliation></author><author><persName><forename type="first">J. Mark</forename><surname>Gibson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation></author><author><persName><forename type="first">Timothy</forename><surname>Lynch</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</affiliation></author><author><persName><forename type="first">Dennis W.</forename><surname>Dickson</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Ryan J.</forename><surname>Uitti</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Zbigniew K.</forename><surname>Wszolek</surname></persName><roleName type="degree">MD</roleName><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Matthew J.</forename><surname>Farrer</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author><author><persName><forename type="first">Owen A.</forename><surname>Ross</surname></persName><roleName type="degree">PhD</roleName><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation></author></analytic><monogr><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="pISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><idno type="DOI">10.1002/(ISSN)1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-02-15"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="455">455</biblScope><biblScope unit="page" to="459">459</biblScope></imprint></monogr><idno type="istex">4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2</idno><idno type="DOI">10.1002/mds.22442</idno><idno type="ArticleID">MDS22442</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2009</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Parkinson's disease</term></item><item><term>FGF20</term></item><item><term>α‐synuclein</term></item><item><term>association study</term></item><item><term>genetics</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article category</head><item><term>Brief Report</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-07-13">Received</change><change when="2008-12-02">Registration</change><change when="2009-02-15">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1531-8257</doi><issn type="print">0885-3185</issn><issn type="electronic">1531-8257</issn><idGroup><id type="product" value="MDS"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="MOVEMENT DISORDERS">Movement Disorders</title><title type="short">Mov. Disord.</title></titleGroup></publicationMeta><publicationMeta level="part" position="30"><doi origin="wiley" registered="yes">10.1002/mds.v24:3</doi><numberingGroup><numbering type="journalVolume" number="24">24</numbering><numbering type="journalIssue">3</numbering></numberingGroup><coverDate startDate="2009-02-15">15 February 2009</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="240" status="forIssue"><doi origin="wiley" registered="yes">10.1002/mds.22442</doi><idGroup><id type="unit" value="MDS22442"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="articleCategory">Brief Report</title><title type="tocHeading1">Brief Reports</title></titleGroup><copyright ownership="thirdParty">Copyright © 2009 Movement Disorder Society</copyright><eventGroup><event type="manuscriptReceived" date="2008-07-13"></event><event type="manuscriptRevised" date="2008-10-02"></event><event type="manuscriptAccepted" date="2008-12-02"></event><event type="firstOnline" date="2009-01-09"></event><event type="publishedOnlineFinalForm" date="2009-02-23"></event><event type="publishedOnlineAcceptedOrEarlyUnpaginated" date="2009-01-09"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:3.3.0 mode:FullText" date="2014-04-14"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.3.0 mode:FullText" date="2014-04-14"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-31"></event></eventGroup><numberingGroup><numbering type="pageFirst">455</numbering><numbering type="pageLast">459</numbering></numberingGroup><correspondenceTo>Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road South, Jacksonville, Florida 32224</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:MDS.MDS22442.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count><count type="referenceTotal" number="16"></count><count type="wordTotal" number="3350"></count></countGroup><titleGroup><title type="main" xml:lang="en"><i>FGF20</i> and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression<link href="#fn1"></link></title><title type="short" xml:lang="en"><fi>FGF20</fi> and Parkinson's Disease</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1 #af2" corresponding="yes"><personName><givenNames>Christian</givenNames><familyName>Wider</familyName><degrees>MD</degrees></personName><contactDetails><email>wider.christian@mayo.edu</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Justus C.</givenNames><familyName>Dachsel</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Alexandra I.</givenNames><familyName>Soto</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Michael G.</givenNames><familyName>Heckman</familyName><degrees>MS</degrees></personName></creator><creator xml:id="au5" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Nancy N.</givenNames><familyName>Diehl</familyName><degrees>BS</degrees></personName></creator><creator xml:id="au6" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Mei</givenNames><familyName>Yue</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au7" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Sarah</givenNames><familyName>Lincoln</familyName><degrees>BSc</degrees></personName></creator><creator xml:id="au8" creatorRole="author" affiliationRef="#af3 #af4"><personName><givenNames>Jan O.</givenNames><familyName>Aasly</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au9" creatorRole="author" affiliationRef="#af1 #af3"><personName><givenNames>Kristoffer</givenNames><familyName>Haugarvoll</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au10" creatorRole="author" affiliationRef="#af5"><personName><givenNames>John Q.</givenNames><familyName>Trojanowski</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au11" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Spiridon</givenNames><familyName>Papapetropoulos</familyName><degrees>MD, PhD</degrees></personName></creator><creator xml:id="au12" creatorRole="author" affiliationRef="#af6"><personName><givenNames>Deborah</givenNames><familyName>Mash</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au13" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Alex</givenNames><familyName>Rajput</familyName><degrees>FRCPC</degrees></personName></creator><creator xml:id="au14" creatorRole="author" affiliationRef="#af7"><personName><givenNames>Ali H.</givenNames><familyName>Rajput</familyName><degrees>FRCPC</degrees></personName></creator><creator xml:id="au15" creatorRole="author" affiliationRef="#af8"><personName><givenNames>J. Mark</givenNames><familyName>Gibson</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au16" creatorRole="author" affiliationRef="#af9"><personName><givenNames>Timothy</givenNames><familyName>Lynch</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au17" creatorRole="author" affiliationRef="#af10"><personName><givenNames>Dennis W.</givenNames><familyName>Dickson</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au18" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Ryan J.</givenNames><familyName>Uitti</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au19" creatorRole="author" affiliationRef="#af2"><personName><givenNames>Zbigniew K.</givenNames><familyName>Wszolek</familyName><degrees>MD</degrees></personName></creator><creator xml:id="au20" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Matthew J.</givenNames><familyName>Farrer</familyName><degrees>PhD</degrees></personName></creator><creator xml:id="au21" creatorRole="author" affiliationRef="#af1"><personName><givenNames>Owen A.</givenNames><familyName>Ross</familyName><degrees>PhD</degrees></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="US" type="organization"><unparsedAffiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af2" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af3" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af4" countryCode="NO" type="organization"><unparsedAffiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</unparsedAffiliation></affiliation><affiliation xml:id="af5" countryCode="US" type="organization"><unparsedAffiliation>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</unparsedAffiliation></affiliation><affiliation xml:id="af6" countryCode="US" type="organization"><unparsedAffiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</unparsedAffiliation></affiliation><affiliation xml:id="af7" countryCode="CA" type="organization"><unparsedAffiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</unparsedAffiliation></affiliation><affiliation xml:id="af8" countryCode="IE" type="organization"><unparsedAffiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</unparsedAffiliation></affiliation><affiliation xml:id="af9" countryCode="IE" type="organization"><unparsedAffiliation>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</unparsedAffiliation></affiliation><affiliation xml:id="af10" countryCode="US" type="organization"><unparsedAffiliation>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">Parkinson's disease</keyword><keyword xml:id="kwd2">FGF20</keyword><keyword xml:id="kwd3">α‐synuclein</keyword><keyword xml:id="kwd4">association study</keyword><keyword xml:id="kwd5">genetics</keyword></keywordGroup><fundingInfo><fundingAgency>Swiss National Science Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Swiss Parkinson Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Robert H. and Clarice Smith and the M.L. Simpson Foundation Trust</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Michael J. Fox Foundation</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Morris K. Udall Center of Excellence for Parkinson's Disease Research</fundingAgency><fundingNumber>P50‐NS40256</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Mayo Clinic ADRC</fundingAgency><fundingNumber>P50‐AG16574</fundingNumber></fundingInfo><fundingInfo><fundingAgency>Pacific Alzheimer Research Foundation (PARF)</fundingAgency><fundingNumber>C06‐01</fundingNumber></fundingInfo><supportingInformation><p> Additional Supporting Information may be found in the online version of this article. </p><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22442:supptable1"></mediaResource><caption>Supporting Table 1: r2 values measuring linkage disequilibrium between markers.</caption></supportingInfoItem><supportingInfoItem><mediaResource alt="supporting information" href="urn-x:wiley:08853185:media:mds22442:SupplementalTable2"></mediaResource><caption>Supporting Table 2: Allele and genotype frequencies.</caption></supportingInfoItem></supportingInformation><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Genetic variation in <i>fibroblast growth factor 20</i> (<i>FGF20</i>) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of <i>FGF20</i> and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between <i>FGF20</i> variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Potential conflict of interest: None reported.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>FGF20 and Parkinson's Disease</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression</title></titleInfo><name type="personal"><namePart type="given">Christian</namePart><namePart type="family">Wider</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation><description>Correspondence: Morris K. Udall Parkinson's Disease Research Center of Excellence, Mayo Clinic, Department of Neuroscience, 4500 San Pablo Road South, Jacksonville, Florida 32224</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Justus C.</namePart><namePart type="family">Dachsel</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alexandra I.</namePart><namePart type="family">Soto</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michael G.</namePart><namePart type="family">Heckman</namePart><namePart type="termsOfAddress">MS</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Nancy N.</namePart><namePart type="family">Diehl</namePart><namePart type="termsOfAddress">BS</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Mei</namePart><namePart type="family">Yue</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sarah</namePart><namePart type="family">Lincoln</namePart><namePart type="termsOfAddress">BSc</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan O.</namePart><namePart type="family">Aasly</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><affiliation>Department of Neurology, St. Olav's Hospital, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kristoffer</namePart><namePart type="family">Haugarvoll</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><affiliation>Department of Neuroscience, Norwegian University of Science and Technology, Trondheim, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">John Q.</namePart><namePart type="family">Trojanowski</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Spiridon</namePart><namePart type="family">Papapetropoulos</namePart><namePart type="termsOfAddress">MD, PhD</namePart><affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Deborah</namePart><namePart type="family">Mash</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neurology, School of Medicine, University of Miami, Miami, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Alex</namePart><namePart type="family">Rajput</namePart><namePart type="termsOfAddress">FRCPC</namePart><affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ali H.</namePart><namePart type="family">Rajput</namePart><namePart type="termsOfAddress">FRCPC</namePart><affiliation>Division of Neurology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J. Mark</namePart><namePart type="family">Gibson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Royal Victoria Hospital, Belfast, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Timothy</namePart><namePart type="family">Lynch</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mater Misericordiae Hospital, Dublin, and University, College Dublin Conway Neuroscience Investigator, Ireland</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Dennis W.</namePart><namePart type="family">Dickson</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neuropathology, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ryan J.</namePart><namePart type="family">Uitti</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Zbigniew K.</namePart><namePart type="family">Wszolek</namePart><namePart type="termsOfAddress">MD</namePart><affiliation>Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Matthew J.</namePart><namePart type="family">Farrer</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Owen A.</namePart><namePart type="family">Ross</namePart><namePart type="termsOfAddress">PhD</namePart><affiliation>Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2009-02-15</dateIssued><dateCaptured encoding="w3cdtf">2008-07-13</dateCaptured><dateValid encoding="w3cdtf">2008-12-02</dateValid><copyrightDate encoding="w3cdtf">2009</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent><extent unit="references">16</extent><extent unit="words">3350</extent></physicalDescription><abstract lang="en">Genetic variation in fibroblast growth factor 20 (FGF20) has been associated with risk of Parkinson's disease (PD). Functional evidence suggested the T allele of one SNP, rs12720208 C/T, altered PD risk by increasing FGF20 and α‐synuclein protein levels. Herein we report our association study of FGF20 and PD risk in four patient‐control series (total: 1,262 patients and 1,881 controls), and measurements of FGF20 and α‐synuclein protein levels in brain samples (nine patients). We found no evidence of association between FGF20 variability and PD risk, and no relationship between the rs12720208 genotype, FGF20 and α‐synuclein protein levels. © 2009 Movement Disorder Society</abstract><note type="content">*Potential conflict of interest: None reported.</note><note type="funding">Swiss National Science Foundation</note><note type="funding">Swiss Parkinson Foundation</note><note type="funding">Robert H. and Clarice Smith and the M.L. Simpson Foundation Trust</note><note type="funding">Michael J. Fox Foundation</note><note type="funding">Morris K. Udall Center of Excellence for Parkinson's Disease Research - No. P50‐NS40256; </note><note type="funding">Mayo Clinic ADRC - No. P50‐AG16574; </note><note type="funding">Pacific Alzheimer Research Foundation (PARF) - No. C06‐01; </note><subject lang="en"><genre>Keywords</genre><topic>Parkinson's disease</topic><topic>FGF20</topic><topic>α‐synuclein</topic><topic>association study</topic><topic>genetics</topic></subject><relatedItem type="host"><titleInfo><title>Movement Disorders</title></titleInfo><titleInfo type="abbreviated"><title>Mov. Disord.</title></titleInfo><genre type="Journal">journal</genre><note type="content"> Additional Supporting Information may be found in the online version of this article.Supporting Info Item: Supporting Table 1: r2 values measuring linkage disequilibrium between markers. - Supporting Table 2: Allele and genotype frequencies. - </note><subject><genre>article category</genre><topic>Brief Report</topic></subject><identifier type="ISSN">0885-3185</identifier><identifier type="eISSN">1531-8257</identifier><identifier type="DOI">10.1002/(ISSN)1531-8257</identifier><identifier type="PublisherID">MDS</identifier><part><date>2009</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>455</start><end>459</end><total>5</total></extent></part></relatedItem><identifier type="istex">4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2</identifier><identifier type="DOI">10.1002/mds.22442</identifier><identifier type="ArticleID">MDS22442</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2009 Movement Disorder Society</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Subscription Services, Inc., A Wiley Company</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000C68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Corpus/biblio.hfd -nk 000C68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Corpus
|type= RBID
|clé= ISTEX:4AD79CC8B3140A1D4F04BA5FC1D17431D1A1E3D2
|texte= FGF20 and Parkinson's disease: No evidence of association or pathogenicity via α‐synuclein expression
}}
| This area was generated with Dilib version V0.6.23. |  |